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The relevance of IGF-1 LR3 peptide in growth factor signaling studies is one of the reasons why it remains highly attractive for cellular adaptation studies, regenerative studies, and endocrinology studies
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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin
Chou IW, Cheng YH, Chen YR, Hsieh PCH, King K
